Ivermectin 1%+Closantel 10% Inj

APPEARANCE

It is an amber to brownish yellow clear liquid.

COMPOSITION

Each ml contains: Ivermectin 10 mg, Closantel: 100mg.

INDICATION

For the treatment of mixed trematode (fluke) and nematode or arthropod infestations due to gastrointestinal roundworms, lungworms, eyeworms, warbles, mites and lice of cattle. One dose of Closamectin Injection effectively controls internal and external parasites that impair the health and productivity of cattle.

Ostertagia ostertagi (including inhibited larval stages), Ostertagia lyrata (adult), Haemonchus placei (adult and immature), Trichostrongylus axei (adult and immature), Trichostrongylus colubriformis (adult and immature), Cooperia oncophora (adult and immature), Cooperia punctata (adult and immature), Cooperia pectinata (adult and immature), Oesophagostomum radiatum (adult and immature), Nematodirus helvetianus (adult), Nematodirus spathiger (adult), Strongyloides papillosus (adult), Bunostomum phlebotomum (adult and immature), Toxocara vitulorum (adult), Trichuris spp.

Lungworms

Dictyocaulus viviparus (adult and 4th stage larvae).

Liver Fluke (trematodes)

Fasciola gigantica, Fasciola hepatica .

Treatment of fluke at 12 weeks (mature) >99% efficacy.

Treatment of fluke at 9 weeks (late immature) >90% efficacy.

Eyeworms (adult)

Thelazia spp.

Cattle grubs (parasitic stages)

Hypoderma bovis, Hypoderma lineatum.

Lice

Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus.

Mange Mites

Psoroptes ovis (syn P communis var bovis), Sarcoptes scabiei var bovis.

Closamectin Injection may also be used as an aid in the control of the biting louse Damalinia bovis and the mange mite Chorioptes bovis, but complete elimination may not occur.

Persistent activity in cattle

Closamectin Injection, at the recommended dose, controls re-infection with.

CONTRAINDICATIONS

Animals must not be slaughtered for human consumption during treatment. Cattle must not be slaughtered for human consumption within 49 days of treatment. Not permitted for use in animals producing milk for human consumption, including pregnant animals intended to produce milk for human consumption. Do not use any closantel-containing products during the 49 day withdrawal period. If an additional ivermectin only product is administered within the 49 day withdrawal period set for Closamectin Injection, care should be taken to observe the longest overall withdrawal period.

MODE OF ACTION

Ivermectin paralyses and ultimately kills parasitic nematodes, arachnids and insects by its effect on the nervous system of these parasites. At therapeutic doses, ivermectin has no adverse effect on cattle since it does not readily penetrate their central nervous systems. Ivermectin belongs to the avermectin class of anthelmintic endectocides. The mode of action exhibited by the avermectins is unique to this class of antiparasitic agents.

Closantel is a member of the salicylanilide class of anthelmintics. Salicylanilides are hydrogen ionophores which act as potent uncouplers of oxidative phosphorylation. The site of action of these proton ionophores is known to be selective uncoupling of oxidative phosphorylation in parasite mitochondria.

Treatment with Closamectin when flukes are five weeks and greater has been shown to reduce subsequent reproductive capacity and egg shedding.

DOSAGE AND ADMINISTRATION ROUTE

Bodyweight and dosage should be accurately determined prior to treatment to avoid underdosing.

Closamectin Injection should be administered at a dosage rate of 200 mcg ivermectin per kg and 5 mg closantel per kg bodyweight. It should be injected subcutaneously in the middle portion of the neck using the aseptic technique. A maximum dose of 10ml should be administered at any one site with any residual volume administered at another site in the neck. The first dose should be injected into the right neck with any residual volumes injected into separate sites on the left and right neck. A sterile 16-gauge, one-inch needle is recommended. Use of a draw-off needle is recommended to avoid excess broaching of the stopper.

Over 300 kg bodyweight give 1 ml per 25 kg bodyweight.

If animals are to be treated collectively rather than individually they should be grouped according to their bodyweight and dosed accordingly, in order to avoid under- or over-dosing.

WARNINGS

Do not use in cases of known hypersensitivity to the active ingredients.

This product is not for intravenous or intramuscular use. Do not smoke, eat or drink while handling the product. Direct contact of the product with the skin should be kept to a minimum. Wash hands after use. Take care to avoid self-injection. Inadvertent self-injection may result in local irritation and/or pain at the injection site.

WITHDRAWAL PERIOD

Meat: 35 days.

Not permitted for use in cattle producing milk for human consumption.

Do not use in non-lactating dairy cows including pregnant heifers which are intended to produce milk

for human consumption within 60 days of expected parturition.

Do not use any closantel-containing products during the 35 day withdrawal period.

VALIDITY

2 years.

PRESENTATION

In a 30 ml, 50 ml or 100 ml bottle.

STORAGE

Stored in a cool, dry and dark place.

visit our website